Vdrl test in pregnancy

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    Sir,

    We read with great interest the CME article titled “VDRL ttest and its interpretation,” which was published in March 2012 (2012; 57(1): 3-8) issue of Indian Journal of Dermatology.[1] The article very clearly and rightly conveyed the facts and misconceptions about this test and its interpretations in pregnant women and in cases of congenital syphilis, neurosyphilis and HIV infection.

    Interpretation of the VDRL test in congenital syphilis was specially excellent as it suggested that all infants born to mothers who have reactive non-treponemal and treponemal tests results should be evaluated with a quantitative RPR/VDRL test performed on infant's serum and not on cord blood.

    Infection in the infant is indicated when the infant's antibody titer is higher than that of the mother and it is shown to rise. Testing of IgM treponemal antibody is not sufficiently reliable to diagnose congenital syphilis.[2] However as microbiologists we would also like to clarify the following points:-

    1. The three basic methods (dark ground microscopy, non-treponemal and treponemal serological tests

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